動的な生体分子群から構成される膜の過渡的な状態の観測を通じて、膜臨界場の挙動と細胞機能の関連に迫ります。
土谷 正樹
Masaki Tsuchiya
静岡県立大学薬学部 統合生理学分野 准教授
原 雄二
Yuji Hara
静岡県立大学薬学部 統合生理学分野 教授
主な発表論文
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Masaki Tsuchiya, Nobuhiko Tachibana, Itaru Hamachi “Flow cytometric analysis of phosphatidylcholine metabolism using organelle-selective click labeling” STAR Protocols, 2023
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Masaki Tsuchiya, Nobuhiko Tachibana, Kohjiro Nagao, Tomonori Tamura, Itaru Hamachi “Organelle-selective click labeling coupled with flow cytometry allows high-throughput CRISPR screening of genes involved in phosphatidylcholine metabolism” Cell Metabolism, 2023
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Kotaro Hirano, Masaki Tsuchiya, Seiji Takabayashi, Kohjiro Nagao, Yasuo Kitajima, Yusuke Ono, Keiko Nonomura, Yasuo Mori, Masato Umeda, Yuji Hara “The mechanosensitive Ca2+-permeable ion channel PIEZO1 promotes satellite cell function in skeletal muscle regeneration” Life Science Alliance, 6, e202201783, 2022.
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Masaki Tsuchiya, Yuji Hara, Masaki Okuda, Karin Itoh, Ryotaro Nishioka, Akifumi Shiomi, Kohjiro Nagao, Masayuki Mori, Yasuo Mori, Junichi Ikenouchi, Ryo Suzuki, Motomu Tanaka, Tomohiko Ohwada, Junken Aoki, Motoi Kanagawa, Tatsushi Toda, Yosuke Nagata, Ryoichi Matsuda, Yasunori Takayama, Makoto Tominaga, Masato Umeda “Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation” Nature Communications, 9, 2049, 2018.
土谷・原班
膜脂質の局所変動を可視化する膜臨界場イメージング技術